Through their work, the ICCF members aim to facilitate the approval or authorization of feed ingredients across jurisdictions to support the feed and food chain as it works to safely and sustainably meet the global growing demand for animal protein.
ICCF produces technical guidance documents that:
- Enable convergence of the risk assessment requirements for the approval or authorization of feed ingredients across different jurisdictions
- May facilitate the recognition of the outcome of risk assessments between different jurisdictions
- Are available for reference and use by other jurisdictions around the globe
- Help feed businesses develop risk assessments for the feed ingredients they manufacture
Published
Five guidance documents have been adopted and published:

#01 – STABILITY TESTING OF FEED INGREDIENTS published in March 2019
This guidance document addresses the storage stability of feed ingredients, as such or when incorporated into their intended matrices (ingredient market formulation, premixtures, feeds, feed supplements and drinking water for animals). It also addresses the in-process stability of feed ingredients, while processing the intended matrices.
Suggested citation: ICCF EWG ‘Stability Testing of Feed Ingredients’. Tang L1 Gwayumba W2, Ponghellini M3, LaMarta J4, Pierre F5, Rivera V6, Lund BT7, 2019. Guidance on the stability testing for feed ingredients. ICCF, 2019. 15 pages
1 FDA / 2 CFIA / 3 DG Sante / 4 AFIA / 5 FEFANA / 6 ANAC / 7 IFIF

#02 – SUB-CHRONIC ORAL TOXICITY TESTING IN LABORATORY ANIMALS published in March 2019
This guidance document addresses the approach to be taken for providing information on potential toxic effects, indicate target organs of toxicity and the possibility of accumulation, and to provide an estimate of a no-observed-adverse-effect level (NOAEL) of feed ingredients.
Suggested citation: ICCF EWG ‘Sub-chronic oral toxicity testing in laboratory animals’. Johnson D1, Muir B2, Ponghellini M3, Matulka R4, Thiel A5, Campbell L6, Eapen A7, 2019. Guidance on the sub-chronic toxicity testing in laboratory animals. ICCF, 2019. 31 pages
1 CFIA / 2 FDA / 3 EFSA / 4 AFIA / 5 FEFANA / 6 ANAC / 7 IFIF

#03 HOMOGENEITY TESTING OF FEED INGREDIENTS published in September 2020
This guidance document addresses the homogeneity testing of feed ingredients, when incorporated into their intended matrices (ingredient market formulation, premixtures, feeds, feed supplements and drinking water for animals)
Suggested citation: ICCF EWG ‘Homogeneity Testing of Feed Ingredients’. Tang L1 Gwayumba W2, Tarres-Call J3, LaMarta J4, Pierre F5, Rivera V6, Lund BT7, 2020. Guidance on the homogeneity testing of feed ingredients. ICCF, 2020. 19 pages
1 FDA / 2 CFIA / 3 EFSA / 4 AFIA / 5 FEFANA / 6 ANAC / 7 IFIF

#04 MANUFACTURING PROCESS AND SPECIFICATION published in July 2021
This guidance document on manufacturing process and specifications provides information for applicants to provide the relevant information on their manufacturing process and the derived specifications for placing a feed ingredient on the market. It is applicable to any feed ingredient.
Suggested citation: ICCF EWG ‘Manufacturing Process and Specification’. Italiano C.1, Anguita M.2, Das M.3, Patterson R.4, Arnaud L.5, Pixley C.6, Wilkins T.7, Guidance on the Manufacturing Process and Specification of Feed Ingredients. 21 pages
1 CFIA / 2 EFSA / 3 FDA / 4 ANAC / 5 FEFANA / 6 AFIA / 7 IFIF

#05 GENOTOXICITY TESTING published in April 2021
This guidance document addresses the approach to be taken for evaluating the genotoxic potential of feed ingredients. It provides recommendations on the approach and on the relevant tests to be used, including their interpretation.
Suggested citation: ICCF EWG ‘Genotoxicity Testing of Feed Ingredients’. Manini P.1, Post L.2, Chen C.Q.3, Thiel A.4, Ladics G.5, Nasir Z.6, Eapen A.7, 2021. Guidance on genotoxicity testing of feed ingredients. ICCF, 2021. 20 pages
1 EFSA / 2 FDA / 3 CFIA / 4 FEFANA / 5 AFIA / 6 ANAC / 7 IFIF
Consultation
There is currently no guidance document open for public consultation.
Activities
Experts Working Groups have been established to develop the following guidance documents:
ENVIRONMENTAL SAFETY ASSESSMENT (PHASE 2) OF FEED INGREDIENTS – Step 2: Initial Drafting
ADME STUDIES IN THE SAFETY ASSESSMENT OF FEED INGREDIENTS – Step 2: Initial Drafting
ANALYTICAL METHODS FOR FEED INGREDIENTS – Step 2 : Initial Drafting
FEED INGREDIENTS ENVIRONMENTAL SAFETY ASSESSMENT APPROACH – Step 6: Submission for adoption to Steering Committee
IDENTIFICATION AND CHARACTERIZATION OF FEED INGREDIENTS – Step 6 : Submission for adoption to Steering Committee

*Note that pdfs are not available for guidance documents currently under development.