ICCF submits its guidance document on ‘Absorption, Distribution, Metabolism and Excretion (ADME) Evaluation in the context of risk assessment of feed ingredients’ for Public Consultation

January 23rd, 2024 – An Expert Working Group of the International Cooperation for Convergence of Technical Requirements for the Assessment of Feed Ingredients (ICCF) composed of experts drawn from the ICCF founding members has developed a new guidance document on ‘ADME Evaluation in the context of risk assessment of feed ingredients’.

The ICCF Steering Committee adopted the draft Guidance Document for Public Consultation on January 9th, 2024.

The Public Consultation on the Guidance Document ‘ADME Evaluation in the context of risk assessment of feed ingredients’ is now open for comments by interested stakeholders until February 23rd, 2024. Stakeholders are invited to submit their comments, using the feedback document available below. The draft guidance document provides recommendations on how to approach the evaluation of the absorption, distribution, metabolism, and excretion of constituent entities contained in the feed ingredient in the context of consumer safety assessment. It provides a stepwise approach, leading, if necessary to ADME Studies on laboratory animals and/or target species.

The draft ICCF Guidance Document and feedback document are available at the following link:

ICCF Technical Guidance Documents (iccffeed.org)

Stakeholders are invited to provide their comments using the feedback document supplied by February 23rd, 2024 (End of Business) via email to [email protected].


About ICCF

The International Cooperation for the Convergence of Technical requirements for the Assessment of Feed Ingredients (ICCF) was created in 2017. It was founded by the Canadian Food Inspection Agency (CFIA) and the Animal Nutrition Association of Canada (ANAC), the United States Food and Drug Administration (FDA) and the American Feed Industry Association (AFIA), the European Commission (DG SANTE)[1] and the EU Association of Specialty Feed Ingredients and their Mixtures (FEFANA), and the International Feed Industry Federation (IFIF). The ICCF aims at developing science-based technical guidance documents supporting the feed industry in assessing their products and to aid in the preparation of pre-market assessment submissions. For more information about the ICCF, please contact the ICCF secretariat at [email protected]


Issued by ICCF

[1] Supported by the European Food Safety Authority (EFSA)

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